A phylogenetic analysis of the Mecinini (Coleoptera: Curculionidae, Curculioninae) was performed to verify the systematic validity of this tribe, to determine its sister group, and to attempt a classification based on the inferred phylogenetic relationships of the included genera and subgenera. From the results obtained by this analysis Cionini are the sister group of Mecinini, whereas Miarini are synonymous with Mecinini. The tribe Mecinini includes the genera Mecinus GERMAR, 1821, Gymnetron SCHÖNHERR, 1825, Rhinusa STEPHENS, 1829, Rhinumiarus gen.n., Cleopomiarus PIERCE, 1919, and Miarus SCHÖNHERR, 1826. Gymnetron subgen. Aprinus DESBROCHERS DES LOGES, 1893 is a junior synonym of Mecinus, and Colabus SCHÖNHERR, 1843 is synonymized with Gymnetron. The following new taxa are described: Rhinumiarus gen.n. and R. lyali sp.n. from central Argentine, Miarus praecursor sp.n. from Greece (Rhodes), Turkey, and Jordan. The following species are newly transferred from Gymnetron to Mecinus: M. aestivus (HOFFMANN, 1956) comb.n., M. alboscutellatus (HUSTACHE, 1913) comb.n., M. bonnairei (DESBROCHERS DES LOGES, 1898) comb.n., M. caucasicus (REITTER, 1907) comb.n., M. concavirostris (STÖCKLEIN, 1950) comb.n., M. crassifemur (ARZANOV, 1991) comb.n., M. desertorum (KOROTYAEV, 1994) comb.n., M. elongatus (BRISOUT DE BARNEVILLE, 1862) comb.n., M. henrici (ARZANOV, 1991) comb.n., M. ictericus (GYLLENHAL, 1838) comb.n., M. labilis (HERBST, 1795) comb.n., M. latiusculus (JACQUELINE DU VAL, 1855) comb.n., M. linnavuorii (KOROTYAEV, 1994) comb.n., M. longirostris (Pic, 1921) comb.n., M. longulus (DESBROCHERS DES LOGES, 1893) comb.n., M. ludyi (REITTER, 1907) comb.n., M. marina (KOROTYAEV, 1984) comb.n., M. marmota (FAIRMAIRE, 1883) comb.n., M. nigronotatus (PIC, 1906) comb.n., M. paratychioides (HOFFMANN, 1965) comb.n., M. pascuorum (GYLLENHAL, 1813) comb.n., M. pipistrellus (MARSEUL, 1876) comb.n., M. pirazzolii (STIERLIN, 1867) comb.n., M. plantaginis (EPPELSHEIM, 1875) comb.n., M. sanctus (DESBROCHERS DES LOGES, 1893) comb.n., M. seriatus (JACQUET, 1888) comb.n., M. simus (MULSANT & REY, 1859) comb.n., M. tychioides (BRISOUT DE BARNEVILLE, 1862) comb.n., M. variabilis (ROSENHAUER, 1856) comb.n., M. zherichini (KOROTYAEV, 1994) comb.n. The two following species are newly transferred from Gymnetron to Rhinusa: R. algiricum (BRISOUT DE BARNEVILLE, 1862) comb.n. and R. mauritii (DESBROCHERS DES LOGES, 1898) comb.n. The Brazilian species Gymnetron kerhaletii BUQUET, 1842 does not belong to Mecinini; although now lacking a proper generic assignation it must be placed in Curculionidae incertae sedis.